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crack get accessLupus retinitis: successful treatment with infliximab. We report the case of a patient with bilateral lupus retinitis, treated with infliximab, in whom this therapy was associated with clinical improvement, improvement of optical coherence tomography findings and resolution of the inflammation. We believe this is the first case of lupus retinitis treated with a biological agent. This case illustrates that infliximab may be a treatment option in lupus retinitis.The effect of progesterone on cognition in older women: results of a randomized trial. The objective of the present trial was to study the cognitive effects of progesterone treatment on healthy postmenopausal women. This was a randomized, placebo-controlled, double-blind, parallel trial. A total of 244 healthy, otherwise healthy postmenopausal women were enrolled from the Cleveland Clinic Geriatrics and Women's Health Study (CWGS). Participants were randomly assigned to receive 100 mg of progesterone daily ( n = 77) or placebo ( n = 77) for six months. The primary outcome was the Trail Making Test, part B (TMT-B), a validated neuropsychological test of visual-spatial working memory. Secondary outcomes included the Mini Mental State Examination (MMSE), the Mini Mental Status Questionnaire (MMQ), the verbal fluency test (VFT), the clock drawing test (CDT), the Hopkins Verbal Learning Test, version 2 (HVLT-R), and the Wisconsin Card Sorting Test (WCST). Baseline demographics, including medical comorbidities, were similar in the two groups. There was no significant difference between the two groups in cognitive function or medication use at baseline. The progesterone group showed statistically significant differences in all four cognitive outcomes at 6 months: a greater increase in HVLT-R recall [standardized mean difference (SMD) = 0.30, 95% confidence interval (CI) = 0.07 to 0.54, P = 0.01] and HVLT-R delay (SMD = 0.23, 95% CI = 0.05 to 0.42, P = 0.01) and a greater decrease in HVLT-R recognition (SMD = -0.37, 95% CI = -0.64 to -0.10, P = 0.01). No significant changes were seen in the MMSE or MMQ. Progester




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